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M94A2637.TXT
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1994-10-25
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Document 2637
DOCN M94A2637
TI Neurological manifestations of HIV infection-AIDS in children.
DT 9412
AU Matusa R; Ilie M; Cernescu C; Borcea A; Marinescu S; Municipal Hospital
Constanta, Bucharest.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):259 (abstract no. PB0467). Unique
Identifier : AIDSLINE ICA10/94369938
AB OBJECTIVE: To observe the neurological manifestations in HIV
infected-AIDS children. METHODS: We have retrospectively reviewed our
cohort of 600 children with HIV infection-AIDS from Constanta, ages 2
months to 7 years. We use clinical study, neurological exam, head
circumference, the DENVER, test, the cerebrospinal fluid (CSF) exam,
computed tomography (CT), and neuropathologic findings. RESULTS:
Neurological manifestations: progressive encephalopathy (15%), static
encephalopathy (40%), seizures (40%), TB meningoencephalitis (8 cases),
bacterial or fungal meningitis, acute aseptic meningitis. Cerebrospinal
Fluid Findings: lymphocytic pleocytosis, and elevations of protein;
detection of HIV-1 core antigen and synthesis of HIV-1 specific
antibodies. Cerebral atrophy, microcephaly were detected by CT scanning
or postmortem. DISCUSSION AND CONCLUSIONS: Central nervous system
involvement in HIV infected children is a frequent and heterogeneous
manifestation.
DE Acquired Immunodeficiency Syndrome/*DIAGNOSIS AIDS Dementia
Complex/*DIAGNOSIS AIDS-Related Opportunistic Infections/*DIAGNOSIS
Brain/PATHOLOGY Child Child, Preschool Cohort Studies Female
Follow-Up Studies Human HIV Infections/*DIAGNOSIS Infant Male
Meningitis/*DIAGNOSIS *Neurologic Examination Tomography, X-Ray
Computed MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).